What is Simparica TRIO?

Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Simparica TRIO requires a prescription from your veterinarian.

Suitable For:

Dogs and Puppies (8 weeks of age or older, weighing 2.8 lbs or more)

Benefits:

• Protects dogs against heartworm disease, ticks & fleas, roundworms & hookworms
• Tasty chewable that dogs love
• Convenient, once-a-month dosing

How does Simparica TRIO work?

Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite. Pyrantel pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.

Cautions:

IMPORTANT SAFETY INFORMATION: Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

Brand Name:

Simparica TRIO (Zoetis)

Generic Name:

Sarolaner, moxidectin, and pyrantel

What is the most important thing I should know about Simparica TRIO?

Simparica TRIO prevents heartworm disease caused by Dirofilaria immitis, kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), and Rhipicephalus sanguineus (brown dog tick), and the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater. It requires a prescription from your veterinarian.

What should I discuss with my veterinarian before giving Simparica TRIO to my pet?

Prior to administration of Simparica TRIO, your dog should be tested for existing heartworm infections. Let your veterinarian know if your dog is pregnant, lactating, or will be used for breeding. Tell your veterinarian if your pet has a hypersensitivity to any of the active ingredients.

How should Simparica TRIO be given?

Simparica TRIO is a flavored chewable tablet that is given by the mouth. It can be given with or without food. Follow your veterinarian's instructions exactly as directed. The recommended minimum dose is 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Dogs weighing 2.8-5.5 lbs should be given one 3 mg sarolaner, 0.06 mg moxidectin, and 12.5 mg pyrantel chewable tablet (Gold Box). Dogs weighing 5.6-11.0 lbs should be given one 6 mg sarolaner, 0.12 mg moxidectin, and 25 mg pyrantel chewable tablet (Purple Box). Dogs weighing 11.1-22.0 lbs should be given one 12 mg sarolaner, 0.24 mg moxidectin, and 50 mg pyrantel chewable tablet (Caramel Box). Dogs weighing 22.1-44.0 lbs should be given one 24 mg sarolaner, 0.48 mg moxidectin, and 100 mg pyrantel chewable tablet (Teal Box). Dogs weighing 44.1-88.0 should be given one 48 mg sarolaner, 0.96 mg moxidectin, and 200 mg pyrantel chewable tablet (Green Box). Dogs weighing 88.1-132.0 lbs should be given one 72 mg sarolaner, 1.44 mg moxidectin, and 300 mg pyrantel chewable tablet (Brown Box).

What are the potential side effects of Simparica TRIO?

Use with caution in dogs with a history of seizures. Simparica TRIO contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica TRIO has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

What happens if I miss giving a dose of Simparica TRIO?

If a dose is missed, give Simparica TRIO immediately and resume monthly dosing.

What happens if I overdose my pet on Simparica TRIO?

If an overdose is suspected, contact your veterinarian immediately.

What should I avoid while giving Simparica TRIO to my pet?

Do not use Simparica TRIO in cats. Simparica TRIO should not be used in dogs less than 8 weeks of age, weighing less than 2.8 lbs. The safe use of Simparica TRIO has not been evaluated in breeding, pregnant, or lactating dogs.

What other drugs will affect Simparica TRIO?

There are no known contraindications for the use of Simparica TRIO.

Storage:

Keep out of reach of children and pets. Store at or below room temperature.

What is Interceptor Plus (milbemycin oxime/praziquantel)?

Interceptor Plus is a monthly, broad spectrum parasiticide used to prevent heartworm disease, as well as treat and control common intestinal parasites including roundworms, hookworms, whipworms and tapeworms. Interceptor Plus offers long-lasting protection in the convenience of a tasty, easy-to-administer chewable. The chewable tablets are chicken flavored, which is an added benefit for dogs suffering from beef allergies. Most dogs love the taste, and you can rest assured that your best friend will be protected against heartworms for a full month. Interceptor Plus requires a prescription from your veterinarian. It is available as a 1-pack (which provides one month of heartworm protection), as a 6-pack (which provides six months of heartworm protection), or as a 12-pack (which provides 12 months of protection).

NOTE: To protect your dog from flea and ticks, try Credelio.

For:

Dogs and Puppies over 6 weeks of age and weighing more than 2 pounds

Benefits:

• Each tablet provides a full month of protection against heartworms, roundworms, hookworms, whipworms and tapeworms
• Tasty, chicken-flavored chewable is easy to administer
• Chewables can be given directly to your dog or broken up and mixed with food
• Available in four weight categories: 2-8 lbs, 8.1-25 lbs, 25.1-50 lbs, and 50.1-100 lbs
• Package includes calendar reminder stickers to help make sure you never miss a dose

How does Interceptor Plus work?

Interceptor Plus contains the active ingredient milbemycin oxime to prevent heartworm disease caused by Dirofilaria immitis as well as treat and control roundworms, hookworms, and whipworms. It also contains praziquantel, which treats tapeworm infection.

Cautions:

For use in dogs and puppies over 6 weeks of age and weighing more than 2 pounds only. Do not use in cats or in humans. Keep this and all drugs out of the reach of children. Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. The safety of Interceptor Plus has not been evaluated in dogs used for breeding or in lactating females.

Brand Name

Interceptor Plus

Generic Name

Milbemycin Oxime (mil-beh-my-sin ox-eem), praziquantel (pr'z-kwn'tl)

Manufacturer:

Elanco

What is the most important thing I should know about Interceptor Plus?

Interceptor Plus is used for the prevention of heartworm disease caused by Dirofilaria immitis, and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis) and adult tapeworm (Taenia pisiformis, Dipylidium canium, Echinococcus multilocularis and Echinococcus granulosus) infections in dogs and puppies over 6 weeks in age and weighing over 2 lbs. Prior to administration of Interceptor Plus (milbemycin oxime/praziquantel), dogs should be tested for existing heartworm infections.

How should Interceptor Plus be given?

Interceptor Plus should be administered orally, once every month, at the minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, and 2.28 mg/lb (5 mg/kg) praziquantel. For heartworm prevention, give once monthly for at least 6 months after exposure. Dogs weighing 2-8 lbs should be given one Interceptor Plus chewable tablet (Orange Box) monthly. Dogs weighing 8.1-25 lbs should be given one Interceptor Plus chewable tablet (Green Box) monthly. Dogs weighing 25.1-50 lbs should be given one Interceptor Plus chewable tablet (Yellow Box) monthly. Dogs weighing 50.1-100 lbs should be given one Interceptor Plus chewable tablet (Blue Box) monthly.

What are the potential side effects of Interceptor Plus?

The following adverse reactions have been reported in dogs after administration of milbemycin oxime or praziquantel: vomiting, diarrhea, depression/lethargy, ataxia, weight loss, convulsions, weakness, and salivation.

What happens if I miss giving a dose of Interceptor Plus?

Give the missed dose as soon as you remember. Do not give a double dose of the medication.

What happens if I overdose my pet on Interceptor Plus?

Contact your veterinarian immediately.

What other drugs will affect Interceptor Plus?

Do not give Interceptor to your pet if your pet is already taking an alternate heartworm medication.